Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland. Electronic address: mimleh@utu.fi. Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland. Department of Pediatrics and Adolescent Medicine, Turku University Hospital, Turku, Finland. Computational Medicine, Faculty of Medicine, University of Oulu & Biocenter Oulu, Oulu, Finland. Department of Public Health, University of Turku, Turku, Finland. Department of Medicine, University of Turku and Division of Medicine, Turku University Hospital, Turku, Finland. National Institute for Health and Welfare, Turku, Finland. Computational Medicine, Faculty of Medicine, University of Oulu & Biocenter Oulu, Oulu, Finland; Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom; NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland; Population Health Science, Bristol Medical School, University of Bristol, Bristol, United Kingdom; Systems Epidemiology, Baker Heart and Diabetes Institute; Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Faculty of Medicine, Nursing and Health Sciences, The Alfred Hospital, Monash University, Melbourne, Victoria, Australia. Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.